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The neurotrophic factors GDNF and BDNF play a very important part in neuroprotection. Selective serotonin-reuptake inhibitors (SSRI), at present utilised as anti-depressants, are noted to have a optimistic influence on neurotrophic issue expression. inside a transgenic MSA mouse model fluoxetine has actually been demonstrated to raise GDNF and BDNF

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